Science & Technology

COVID-19 mRNA Vaccine Approach Exhibits Promise for Treating Heart Illness

Heart Vaccine Syringe

COVID-19 mRNA vaccines use lipid nanoparticles to ship mRNA to the physique’s cells. The same methodology for delivering genetic materials to the physique is being examined as a approach to heal broken coronary heart muscle after a coronary heart assault.

A method for delivering genetic materials to the physique is being investigated as a method of repairing broken coronary heart muscle after a coronary heart assault. The groundbreaking analysis examine will probably be offered right now (April 30, 2022) at Frontiers in CardioVascular Biomedicine 2022, a scientific congress of the European Society of Cardiology (ESC).[1]

The COVID-19 messenger RNA (mRNA) vaccines[2] use lipid nanoparticles (tiny fats droplets) to ship mRNA to the physique’s cells. This mRNA tells cells to supply a dummy spike protein on their floor in an effort to imitate the protein on the virus that causes COVID-19. After that, the physique creates an immune response by producing antibodies which may be employed if the person turns into contaminated with the virus.

The present analysis examine employed an analogous technique for mRNA supply. However, quite than eliciting an immune response, the researchers’ final aim is to instruct the center’s cells to restore themselves after a coronary heart assault.

This preliminary examine was carried out to find out whether or not mRNA may very well be efficiently delivered to the center muscle in lipid nanoparticles. The researchers injected completely different formulations into the left ventricular wall of mouse hearts throughout open chest surgical procedure below normal anesthesia. Twenty-four hours after administration, the mice have been sacrificed and the placement of mRNA translation was examined.

The researchers discovered that mRNA efficiently reached the center cells 24 hours after injection. However, regardless of injection into the center, the very best ranges of mRNA translation have been present in cells of the liver and spleen.

Study writer Dr. Clara Labonia of the University Medical Center Utrecht, the Netherlands stated: “High expression was expected in the liver, since it metabolizes the lipid nanoparticles. Nonetheless, it was encouraging to see that there was mRNA translation in the heart tissue which means that lipid nanoparticles could work as delivery systems for mRNA therapy.”

She concluded: “The next step of this research is to test more formulations and choose the one which most efficiently targets the heart tissue. We will then assess whether delivery of mRNA to mice with ischaemic hearts (resembling a heart attack) has any therapeutic effect.”

References and notes

  1. The summary “Modified mRNA delivery to the heart using lipid nanoparticles” will probably be offered in the course of the session “Young Investigator Award – Novelties in cardiovascular disease mechanism” which takes place on 30 April at 11:30 CEST in Lecture Room 3.
  2. The COVID-19 mRNA vaccines embody Pfizer-BioNTech and Moderna.

Funding: Funding was supplied by the Dutch Heart Foundation (Dr. E. Dekker Senior Scientist grant, no. 2019T049).

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